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Integrated payer, PBM, and retail pharmacy (Aetna, Caremark, about 9,000 stores). Caremark holds the strongest single lever over US GLP-1 access: it made Wegovy the preferred weight-management drug from July 2025 and removed Zepbound, then added Zepbound back at the same tier effective October 1, 2026.
2021-Q2-2026-Q1
1993-2025

$CVS
The strongest single lever over US GLP-1 access. Caremark made Wegovy the preferred weight-management drug from July 1, 2025 and removed Zepbound, shifting share to Novo, then added Zepbound back at the same formulary tier effective October 1, 2026. Also dispenses at retail and insures through Aetna.