Peptide API (SPPS) Capacity by Provider
Cumulative solid-phase peptide synthesis (SPPS) reactor capacity in liters by provider, 2022 through 2028E.
Updated at 2026-05-22
Sterile Fill-Finish Capacity by Site
Major sterile fill-finish sites for GLP-1 pen and cartridge production, ranked by approximate annual pen-equivalent capacity.
Updated at 2026-05-22
Cumulative CDMO + In-House Capex 2023 to 2027
Cumulative announced peptide-platform capex 2023 to 2027, stacked by participant. Lilly's in-house buildout dwarfs the rest; Novo's $16.5B Catalent deal is included.
Updated at 2026-05-22
FDA Shortage and Compounding Rulemaking Timeline
FDA shortage tracking for the four GLP-1 molecules under compounding, plus the April 2026 proposal to drop them from the 503B bulks list (comments close June 29, 2026).
2022
2023
2024
2025
2026
2027
Tirzepatide (Mounjaro, Zepbound)
Semaglutide (Ozempic, Wegovy)
Liraglutide (Saxenda)
Dulaglutide (Trulicity)
Dec 2022
Tirzepatide added to FDA shortage list (Mounjaro launch ramp)
Tirzepatide added to FDA shortage list (Mounjaro launch ramp)
Dec 2024
Tirzepatide shortage resolved by FDA
Tirzepatide shortage resolved by FDA
Feb 2025
Semaglutide shortage resolved by FDA
Semaglutide shortage resolved by FDA
Apr 2026
FDA proposes removing semaglutide, tirzepatide, liraglutide from 503B bulk substances list
FDA proposes removing semaglutide, tirzepatide, liraglutide from 503B bulk substances list
Jun 2026
Public comment period closes June 29, 2026
Public comment period closes June 29, 2026
Updated at 2026-05-31
Compounded GLP-1 Shadow Market (Modeled Monthly Volume)
Modeled monthly compounded GLP-1 fills in non-traditional channels (503A pharmacies, telehealth 503Bs), peaking during the FDA shortages then declining.
Updated at 2026-05-22